Oct 21, 2025 · Artificial Intelligence

BindCraft Enables Direct AlphaFold2‑Driven Intelligent Protein Binder Design (46% Success on 12 Targets)

BindCraft, an open‑source pipeline from EPFL and MIT, uses AlphaFold2 gradient back‑propagation to design protein binders without manual scaffolding, achieving an average 46.3% success rate across 12 challenging targets and offering a one‑click tutorial for rapid experimentation.

AlphaFold2BindCraftDeep Learning

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BindCraft Enables Direct AlphaFold2‑Driven Intelligent Protein Binder Design (46% Success on 12 Targets)

DataFunSummit

Jun 26, 2023 · Artificial Intelligence

Advances in Graph Neural Networks and Graph Representation Learning for Protein Modeling

This article reviews the fundamentals of graph neural networks and graph representation learning, explains why proteins can be modeled as graphs, and surveys recent GNN‑based applications such as structure prediction, function annotation, protein design, and self‑supervised representation learning, concluding with future research directions.

AlphaFold2bioinformaticsgraph neural networks

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Advances in Graph Neural Networks and Graph Representation Learning for Protein Modeling