HyperAI Super Neural

Oct 15, 2025 · Artificial Intelligence

Ctrl‑DNA: A Constrained RL Framework for Cell‑Specific Gene Expression Selected for NeurIPS 2025

The paper introduces Ctrl‑DNA, a constrained reinforcement‑learning framework that jointly maximizes regulatory activity in target cells while limiting off‑target activity, leveraging a pretrained DNA language model, Lagrangian relaxation, and TF‑binding‑site regularization, and demonstrates superior performance over eight baselines on human promoter and enhancer datasets across six cell types.