SmartApe AI

Oct 14, 2026 · Artificial Intelligence

PhiFold: AI Designs Protein Motion, Not Just Structure, with 10,000x Speedup

Researchers from Peking, Fudan, and Tsinghua universities introduce PhiFold, a generative model that unifies protein structure generation with near-equilibrium dynamics modeling, enabling controllable local flexibility and collective motion via physics-structured covariance decomposition, achieving up to 10,000x faster conformational sampling than MD baselines.