HyperAI Super Neural

Nov 7, 2025 · Artificial Intelligence

How PLACER Tackles Atomic‑Level Modeling of Protein Conformational Heterogeneity

The PLACER graph‑neural‑network framework from David Baker’s lab generates atom‑accurate small‑molecule structures and protein‑ligand conformational ensembles, trained on large CSD and PDB datasets, achieving sub‑Å precision, outperforming traditional docking in many benchmarks and markedly improving enzyme‑design success rates.