Data Party THU

Aug 28, 2025 · Artificial Intelligence

BackFlip & FliPS: Neural Models for Predicting and Generating Protein Flexibility

BackFlip is an equivariant neural network that predicts per‑residue flexibility from protein backbone structures, while the derived FliPS conditional flow‑matching model generates novel backbones matching desired flexibility distributions, demonstrated through diverse designs validated by molecular dynamics simulations, with code available on GitHub.