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Jun 4, 2026 · Fundamentals

How Genome-Scale Models Redefine Marine Heterotrophs Beyond the Copiotrophic‑Oligotrophic Dichotomy

Using genome‑scale metabolic models and unsupervised machine learning on 220 marine bacterial genomes, researchers identified eight distinct metabolic clusters, overturning the traditional copiotrophic‑oligotrophic split and revealing detailed substrate preferences, growth rates, and global distribution patterns of marine heterotrophs.