gradient optimization — 2 Technical Articles

Oct 21, 2025 · Artificial Intelligence

BindCraft Enables Direct AlphaFold2‑Driven Intelligent Protein Binder Design (46% Success on 12 Targets)

BindCraft, an open‑source pipeline from EPFL and MIT, uses AlphaFold2 gradient back‑propagation to design protein binders without manual scaffolding, achieving an average 46.3% success rate across 12 challenging targets and offering a one‑click tutorial for rapid experimentation.

AlphaFold2BindCraftEPFL

0 likes · 5 min read

BindCraft Enables Direct AlphaFold2‑Driven Intelligent Protein Binder Design (46% Success on 12 Targets)

AI Frontier Lectures

Jul 31, 2025 · Artificial Intelligence

Can a 32‑Token Compressor Generate Images Without Training?

This article reviews a recent study that demonstrates how a highly compressed one‑dimensional tokenizer, using only 32 discrete tokens and gradient‑based test‑time optimization, can generate high‑quality images without training a separate generative model, and explores its methodology, findings, applications, and limitations.

1D tokenizerAI researchImage Generation

0 likes · 10 min read

Can a 32‑Token Compressor Generate Images Without Training?