Data Party THU

Aug 21, 2025 · Artificial Intelligence

How AI Is Unlocking the Design of Proteins That Target Disordered Regions

This article reviews the AI‑driven Logos strategy for designing proteins that can bind intrinsically disordered protein regions, detailing scaffold generation, pocket specialization, RFdiffusion‑based assembly, threading, experimental validation, and its broader impact on drug discovery for diseases such as cancer and Alzheimer’s.