Machine Learning Algorithms & Natural Language Processing

Feb 20, 2026 · Artificial Intelligence

AlphaFold 4 Goes Closed‑Source: IsoDDE Beats AlphaFold 3 in Drug Design

Google's Isomorphic Labs unveiled IsoDDE, dubbed AlphaFold 4, which dramatically outperforms AlphaFold 3 on hard protein‑structure benchmarks and antibody‑binding predictions, yet the model is fully closed‑source, sparking a debate about the future of open scientific AI.