HyperAI Super Neural

Oct 27, 2025 · Artificial Intelligence

MIT’s Open‑Source BoltzGen Achieves nM‑Level Affinity for 66% of Targets Across Molecular Types

BoltzGen, an all‑atom generative model released by MIT and collaborators, unifies protein folding and binder design with a geometric continuous representation and a flexible design language, training on multimodal datasets and demonstrating nM‑level affinity for 66% of 26 diverse targets including proteins, nanobodies, peptides and small molecules.