Data Party THU
Jul 30, 2025 · Artificial Intelligence
Can Graph Neural Networks Accurately Predict Antibody‑Antigen Binding Affinity?
A recent Oxford study introduces Graphinity, an equivariant graph neural network that directly uses antibody‑antigen structures to predict ΔΔG, achieving up to r = 0.89 on large synthetic datasets, but reveals that data volume and diversity, rather than model architecture, remain the primary bottleneck for reliable affinity prediction.
Protein Engineeringantibody affinitygraph neural networks
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