AI‑Driven De Novo Design of Small‑Molecule Binding Proteins Selective for Cortisol

A KAIST team used deep‑learning‑based protein structure generation and sequence design, employing an NTF2‑like fold as a universal backbone, to de novo create a library of small‑molecule binding proteins, successfully engineering a cortisol‑specific binder and converting it into an AI‑powered biosensor, with structural validation and specificity assays confirming high affinity and selectivity.

AI protein designAlphaFoldProteinMPNN

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AI‑Driven De Novo Design of Small‑Molecule Binding Proteins Selective for Cortisol

IT Services Circle

May 11, 2025 · Fundamentals

Why Software Can Run Across Different CPU Architectures and Operating Systems: Rosetta, Universal Binaries, and Compatibility Techniques

The article explains why software copied between Windows and macOS or between Intel‑based and ARM‑based Macs may or may not run, covering CPU instruction set incompatibility, OS API differences, and the translation or packaging solutions such as Rosetta, Universal Binaries, Wine, compilers, and virtual machines.

CPU architectureRosettaSoftware Compatibility

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Why Software Can Run Across Different CPU Architectures and Operating Systems: Rosetta, Universal Binaries, and Compatibility Techniques

Python Programming Learning Circle

Oct 13, 2019 · Artificial Intelligence

Can AI Really Regulate Online Speech? Insights from the NBA‑China Fallout

The article examines the NBA's China controversy, the massive Chinese backlash, the subsequent suspension of partnerships, and explores how artificial intelligence tools like Facebook's Rosetta are being used—and limited—in moderating online speech, highlighting the balance between automated detection and human review.

AI moderationChinaNBA

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Can AI Really Regulate Online Speech? Insights from the NBA‑China Fallout