HyperAI Super Neural

Apr 15, 2026 · Artificial Intelligence

AI‑Driven De Novo Design of Small‑Molecule Binding Proteins Selective for Cortisol

A KAIST team used deep‑learning‑based protein structure generation and sequence design, employing an NTF2‑like fold as a universal backbone, to de novo create a library of small‑molecule binding proteins, successfully engineering a cortisol‑specific binder and converting it into an AI‑powered biosensor, with structural validation and specificity assays confirming high affinity and selectivity.