two-compartment model

Model Perspective

Jul 19, 2022 · Fundamentals

How to Model Drug Distribution and Elimination Using a Two‑Compartment Pharmacokinetic Model

This article explains the assumptions, equations, and parameter‑estimation methods of a two‑compartment pharmacokinetic model for describing drug distribution, transfer between central and peripheral spaces, and elimination, and compares common dosing routes such as rapid IV bolus, constant‑rate infusion, and oral or intramuscular administration.