AlphaGenome on Nature Cover: Predicts Variant Effects Across All Modalities in <1 s
DeepMind’s AlphaGenome, showcased on Nature’s cover, processes 1 Mb DNA sequences at single‑base resolution to predict thousands of regulatory attributes across cell types, using a U‑Net‑style architecture and two‑stage pre‑training plus distillation, achieving state‑of‑the‑art performance on 24 benchmarks and delivering variant‑effect scores in under one second on an H100 GPU.
