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Data Party THU
Data Party THU
Jun 1, 2026 · Artificial Intelligence

Beyond AlphaFold: ESMFold2 Launches with a 1‑Billion‑Protein Open Atlas

ESMFold2, an open‑source protein‑language‑model predictor, now offers predictions for 1 billion structures and a 6.8 billion‑sequence Atlas, delivering faster, more accurate antibody and protein‑interaction designs than AlphaFold3, while demonstrating experimental success and revealing novel CRISPR‑like proteins, though atypical cases still need careful validation.

AlphaFoldESM AtlasESMFold2
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Beyond AlphaFold: ESMFold2 Launches with a 1‑Billion‑Protein Open Atlas